Index/Topics/PDE-5 Inhibitors

PDE-5 Inhibitors

Medications used in combination with vacuum erection device therapy for erectile dysfunction

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9 results
Jan 12, 2026
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Who should avoid using a vacuum erection device for ED?

Vacuum erection devices (VEDs) are an effective, noninvasive option for many men with erectile dysfunction (ED), but there are clear clinical situations in which they are discouraged or require extrem...

Jan 15, 2026

What role do PDE5 inhibitors or topical agents play in orgasm and sensation after a prosthesis?

Penile prostheses mechanically restore rigidity for penetrative sex but do not re-create the neurovascular mechanisms that produce natural erections, and most guidelines and studies emphasize that imp...

Jan 14, 2026

Which peer‑reviewed studies have evaluated vacuum erection therapy for post‑prostatectomy penile rehabilitation?

Peer‑reviewed clinical studies of vacuum erection devices (VEDs) as penile rehabilitation after radical prostatectomy include small randomized controlled trials, prospective controlled trials, pilot p...

Jan 14, 2026

Are there patient characteristics that predict better tolerability of one PDE5 inhibitor over another?

Yes — some patient characteristics can guide which PDE5 inhibitor is likely to be better tolerated, but the signal is modest: pharmacokinetic differences (half‑life, food interactions), cardiovascular...

Jan 11, 2026

Which sexual‑enhancement supplements have been recalled or found to contain prescription drugs since 2010?

Since 2010 dozens of sexual‑enhancement products marketed as “natural” dietary supplements have been recalled or publicly warned about after laboratory testing found undeclared prescription drugs—most...

Jan 9, 2026

What does current clinical research say about l-arginine vs l-citrulline for erectile dysfunction effectiveness?

Clinical research shows both L-arginine and L-citrulline can modestly improve erectile function in some men, particularly those with mild to moderate or vasculogenic ED, but evidence is stronger and m...

Jan 8, 2026

What clinical trials exist for L‑arginine or CBD in treating erectile dysfunction?

Clinical trial evidence supports some benefit of L‑arginine for mild-to-moderate erectile dysfunction (ED), both as a single high‑dose agent and in combination products—yet results are mixed across st...

Jan 8, 2026

Impact of penis girth on erectile dysfunction diagnosis

Penile girth (circumference) shows little consistent association with objective erectile dysfunction (ED) in clinical research: measured girth often does not differ significantly between men with and ...

Jan 7, 2026

Are herbal remedies like ginseng, yohimbe, and horny goat weed effective and safe for erectile dysfunction?

Herbal remedies such as red ginseng, yohimbe/yohimbine and horny goat weed are widely marketed for erectile dysfunction (ED) and have some biological rationale and mixed clinical signals, but the clin...